Category: Tn Antigen

Fmoc-Ser(GalNAc(Ac)₃-α-D)-OH

Tumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy. This product is Fmoc and acetyl protected for use in solid phase peptide synthesis and other types of syntheses.

Other Names: Tn Epitope (Serine); Tn Antigen (Serine, Fmoc, Peracetylated); Fmoc-L-Ser(GalNAc(Ac)₃-α-D)-OH; Fmoc-Ser(α-D-GalNAc(Ac)₃)-OH; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-α-D-galactopyranosyl)-L-Serine; N-(9-fluorenylmethoxycarbonyl)-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-galactopyranosyl)-L-Serine; Fmoc-Ser(α-D-GalNAc(Ac)3)-OH; Fmoc-Ser[GalNAc(Ac)3-α-D]-OH; Fmoc-Ser(α-D-GalNAc)-OH, Peracetate

References: T. Ju, V.I. Otto and R.D. Cummings Angew. Chem. Int. Ed. 2011, 50, 1770 – 1791