Product #: GA121010

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Category: TF Antigen

Fmoc-Ser(Galβ(1-3)GalNAc)-OH (Peracetate)

Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.

Other Names: TF Epitope (Serine); T Antigen (Serine,Fmoc, Peracetylated); Thomsen–Friedenreich Antigen; Core 1 Glycan (Serine); Fmoc-L-Ser(Galβ(1-3)GalNAc)-OH (Peracetate); Fmoc-Ser[β-Gal(Ac)4-(1-3)-α-GalNAc(Ac)2]-OH; O-{2-N-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-N α-(fluoren-9-yl-methoxycarbonyl)-L-Serine; Fmoc-Ser(α-Gal-β(1-3)-GalNAc)-OH, Peracetate

References: F.J. Irazoqui et al., Immunology and Cell Biology 2005, 83, 405–412

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$700.00 USD
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