Category: N-Acetyl-D-glucosamine

Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH

O-GlcNAc on proteins plays fundamental roles as a cellular nutrient and stress sensor and thus central in the etiologies of chronic diseases of aging, including diabetes, cancer and neurodegenerative disease. In dynamic protein glycosylation, reversible β-O-GlcNAc modification of nuclear and cytoplasmic proteins at serine and threonine controls diverse aspects of cell physiology and is conceptually analogous to phosphorylation.

Other Names: O-GlcNAc / Threonine; Fmoc-L-Thr(GlcNAc(Ac)₃-β-D)-OH; N-α-Fmoc-O-β-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-threonine; Fmoc-Thr(β-D-GlcNAc)-OH, Peracetate; Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH; N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl)-L-threonine

References: Hart G.W. et al., Annu. Rev. Biochem., 2011, 80, 825-858 Hart G.W., J. Biol. Chem. 2019, 294, 2211-2231.