MUC1(135-145-Lys(5-FAM))-STF(139)

Synthetic glycopeptide. Glycosylated Mucin-1 (MUC1) peptide fragment containing amino acid sequence Ala135–Arg150 (15 AA in length) from the tandem repeat (TR) region of the MUC1 protein. Tumour-associated carbohydrate antigen (TACA), Sialyl-TF (STF or ST) antigen, O-glycosylation (Neu5Acα2-3Galβ1-3GalNAc) at Thr139. The ε-amine of C-terminus lysine accommodates the FAM label.

Sequence:

Ac-AHGVT*SAPDTRK(5-FAM)-NH₂
Ac-Ala-His-Gly-Val-Thr*-Ser-Ala-Pro-Asp-Thr-Arg-Lys-(5-FAM)-NH₂
where T* = Thr* = Sialyl TF = STF = Neu5Acα2-3Galβ1-3GalNAcα-O-Thr and 5-FAM = 5-carboxyfluorescein