Biotin DADPS Picolyl Azide Labeling Probe

A cleavable Biotin Probe for Labeling of Biomolecules via Azide–Alkyne Cycloaddition (Click Chemistry). The Biotin moiety is linked via a PEG spacer and cleavable dialkoxydiphenylsilane (DADPS) linker to a picolyl azide group for click chemistry. B. Calle et al. J. Am. Soc. Mass Spectrom. 2021.

Other Names: Biotin PEG4-DADPS Picolyl Azide Labeling Probe; DADPS Biotin Picolyl Azide Labeling Probe

References: Schumann, B., Malaker, S. A., Wisnovsky, S. P., Debets, M. F., Agbay, A. J., Fernandez, D., Wagner, L. J. S., Lin, L., Li, Z., Choi, J., Fox, D. M., Peh, J., Gray, M. A., Pedram, K., Kohler, J. J., Mrksich, M., & Bertozzi, C. R. (2020). Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells. Molecular cell, 78(5), 824–834.e15.