GalNAcα

N-acetylgalactosamine (GalNAcα) ligands can be used to target drugs to hepatocytes in the liver, by exploiting the asialoglycoprotein receptor (ASGPR). ASGPR has a high affinity for GalNAc-containing ligands. Therapeutic payloads can be directly conjugated to GalNAc ligands or encapsulated in nanoparticles decorated with GalNAc ligands.

Terminal GalNAcα ligands are substrates for glycosyltransferases, including galactosyltransferases and sialyltransferases.

We provide GalNAcα ligands with various functional linkers depending on their intended use.

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  • AG124000: α-D-GalNAc-Ethyl-Azide

    α-D-GalNAc-Ethyl-Azide

    Product #: AG124000
    Category: N-Acetylgalactosamine Ligand
    CAS #: 195384-42-0

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  • AG142000: α-D-GalNAc-Butyl-Carboxylic Acid

    α-D-GalNAc-Butyl-Carboxylic Acid

    Product #: AG142000
    Category: N-Acetylgalactosamine Ligand
    CAS #: N/A

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  • AG142010: α-GalNAc-Butyl-Carboxy Methyl Ester
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    α-GalNAc-Butyl-Carboxy Methyl Ester

    Product #: AG142010
    Category: N-Acetylgalactosamine Ligand
    CAS #: N/A

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  • BT100000: α-D-GalNAc-PEG3-Biotin

    α-D-GalNAc-PEG3-Biotin

    Product #: BT100000
    Category: N-Acetyl-D-galactosamine
    CAS #: N/A

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  • BT100010: α-D-GalNAc-Ser-NH-Biotin

    α-D-GalNAc-Ser-NH-Biotin

    Product #: BT100010
    Category: Tn Antigen
    CAS #: N/A

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  • BT100020: α-D-GalNAc-Thr-NH-Biotin

    α-D-GalNAc-Thr-NH-Biotin

    Product #: BT100020
    Category: Tn Antigen
    CAS #: N/A

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  • PE105000: α-GalNAc-PEG5000-Thiol

    α-GalNAc-PEG5000-Thiol

    Product #: PE105000
    Category: N-Acetylgalactosamine Ligand
    CAS #: N/A

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  • PE131000: α-GalNAc-PEG3-Alkyne

    α-GalNAc-PEG3-Alkyne

    Product #: PE131000
    Category: N-Acetylgalactosamine Ligand
    CAS #: N/A

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  • PE132000: α-GalNAc-PEG3-Acid

    α-GalNAc-PEG3-Acid

    Product #: PE132000
    Category: N-Acetylgalactosamine Ligand
    CAS #: N/A

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  • PE132040: α-GalNAc-PEG3-NHS Ester
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    α-GalNAc-PEG3-NHS Ester

    Product #: PE132040
    Category: N-Acetylgalactosamine Ligand
    CAS #: N/A

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  • PE133000: α-GalNAc-PEG3-Amine

    α-GalNAc-PEG3-Amine

    Product #: PE133000
    Category: N-Acetylgalactosamine Ligand
    CAS #: 267227-84-9

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  • PE134000: α-GalNAc-PEG3-Azide

    α-GalNAc-PEG3-Azide

    Product #: PE134000
    Category: N-Acetylgalactosamine Ligand
    CAS #: 882873-70-3

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  • PE135000: α-GalNAc-PEG3-Thiol

    α-GalNAc-PEG3-Thiol

    Product #: PE135000
    Category: N-Acetylgalactosamine Ligand
    CAS #: 1245285-20-4

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  • PE142000: α-GalNAc-PEG4-Acid

    α-GalNAc-PEG4-Acid

    Product #: PE142000
    Category: N-Acetylgalactosamine Ligand
    CAS #: N/A

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