Product #: GA121015
Category: STn Antigen
Fmoc-Ser(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester)
Tumor-Associated Carbohydrate Antigen (TACA). STn is a sialylated form of the truncated O-glycosylated core determinant Tn with structure: Neu5Acα2-6GalNAcα-O-Ser/Thr. STn results from an early sialylation of the Tn antigen due to overexpression of the enzyme STn synthase (ST6GalNAc-I) and/or disruption of further glycan elongation processes. STn is negligibly expressed in healthy tissues but overexpressed in >80% of human carcinomas. As such, STn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STn a prime target for cancer immunotherapy.
Other Names: STn Epitope (Serine); STn Antigen (Serine); Sialyl-Tn Antigen; Fmoc-L-Ser(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester); Fmoc-Ser(α-L-Neu5Ac(Ac)4-(2-6)-α-D-GalNAc(Ac)2)-OH, Benzyl Ester; Fmoc-Ser(STn)-OH (Bn, peracetate, free acid)
References: J. Munkley, Int J Mol Sci. 2016, 17, 275; M. Sletmoen, et al. Glycobiology 2018, 28, 437–442
$950.00 USD
Product Details
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Technical Data
CAS #: 914456-67-0
Formula: C56H65N3O24
Molecular Weight: 1164.12
Purity: >95% (HPLC)
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Storage & Shipping
Shipping requirement: Dry Ice
Storage conditions: -20°C
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Documentation
Email: info@sussex-research.com