FZD8 (541-549)-d8 labelled-STF(541)

FZD8(UniProt ID Q9H461) synthetic glycopeptide fragment(Thr541-Ala549; UniProt position 541-549, aa length 9) with Sialyl TF (Neu5Acα2-3Galβ1-3GalNAc) at Thr541. Val542 has been labelled with d8. The C-terminus is carboxylic acid. Antiproliferative factor (APF) is a sialoglycopeptide that contains the transmembrane segment of Frizzled 8, a protein encoded by the FZD8 gene. Highly elevated levels of APF have been associated with interstitial cystitis. Abnormal Akt signaling in bladder epithelial cell explants from patients with interstitial cystitis/bladder pain syndrome can be induced by antiproliferative factor treatment of normal bladder cells.

Sequence:

T*V(d8)PAAVVVA-OH
H-Thr*-Val-(d8)-Pro-Ala-Ala-Val-Val-Val-Ala-OH
where T* = Thr* = Sialyl TF = STF = Neu5Acα2-3Galβ1-3GalNAcα-O-Thr