Biotin-HHV1-gB(50-56)-STn(53)

Herpes simplex virus-1 (HSV-1 or HHV-1) Glycoprotein B (gB) glycopeptide fragment (50-56) is an envelope protein that is essential for viral growth. Before entering host cells, HSV-1 uses this glycopeptide ligand to bind paired immunoglobulin-like type 2 receptor α (PILRα) on immune cells. PILRα belongs to the Siglec (sialic acid-binding immunoglobulin-like lectin)-like family, members of which bind sialic acid ligands. HHV1-gB(UniProt ID P08665) synthetic glycopeptide HSV-1 gB fragment (Gly50-Pro56; UniProt position 50-56, aa length 7) from the N-terminal region of Herpes Simplex Virus type-1 glycoprotein B. O-glycosylation, Sialyl Tn (Neu5Acα2-6GalNAcα-O-Thr) at position Thr53. Biotin has been conjugated at N-terminus. The C-terminus is an amide.

Sequence:

Biotin-GPAT*PAP-NH₂
Biotin-Gly-Pro-Ala-Thr*-Pro-Ala-Pro-NH₂
where T* = Thr* = Thr(Sialyl Tn) = Thr(STn) = Neu5Acα2-6GalNAcα-O-Thr