MUC1(126-149)-STn(139,140)

MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Pro126-Gly149; UniProt position 126-149, aa length 24) from the variable number tandem repeat (TR) domain. The fragment contains tumour-associated carbohydrate antigen (TACA), Sialyl Tn or STn (Neu5Acα2-6GalNAcα-O-Ser) at Ser140 and Neu5Acα2-6GalNAcα-O-Thr at Thr139. The C-terminus is carboxylic acid.

Sequence:

PAPGSTAPPAHGVT*S*APDTRPAPG-OH
H-Pro-Ala-Pro-Gly-Ser-Thr-Ala-Pro-Pro-Ala-His-Gly-Val-Thr*-Ser*-Ala-Pro-Asp-Thr-Arg-Pro-Ala-Pro-Gly-OH
where T* = Thr* = Thr(Sialyl Tn) = Thr(STn) = Neu5Acα2-6GalNAcα-O-Thr and S* = Ser* = Ser(Sialyl Tn) = Ser(STn) = Neu5Acα2-6GalNAcα-O-Ser