GP100095

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RPB1 CTD(1615-1621-Lys)-Tn(1619)

DNA-directed RNA polymerase II (Pol II) subunit RPB1 contains a Carboxy Terminal Domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. The CTD Nonconsensus Repeat, Tyr-Ser-Pro-Thr-Ser-Pro-Ser, is heavily modified by phosphorylation, glycosylation and proline isomerization. The CTD acts as a tether to bring into close proximity the machinery necessary to synthesize and process Pol II transcripts.


Sequence:

YSPTS*PSK-NH2
H-Tyr-Ser-Pro-Thr-Ser*-Pro-Ser-Lys-NH2
where S* = Ser* = GalNAcα-O-Ser

RPB1 CTD(1615-1621-Lys)-Tn(1619)

DNA-directed RNA polymerase II (Pol II) subunit RPB1 contains a Carboxy Terminal Domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. The CTD Nonconsensus Repeat, Tyr-Ser-Pro-Thr-Ser-Pro-Ser, is heavily modified by phosphorylation, glycosylation and proline isomerization. The CTD acts as a tether to bring into close proximity the machinery necessary to synthesize and process Pol II transcripts.


Sequence:

YSPTS*PSK-NH2
H-Tyr-Ser-Pro-Thr-Ser*-Pro-Ser-Lys-NH2
where S* = Ser* = GalNAcα-O-Ser

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      • For research and development use only
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      • Other Names

        RNA polymerase B at C-terminal domain(CTD); RPB1 CTD(Tn) glycopeptide

      • Technical Data

        UniProt ID: P24928

        Formula: C46H73N11O18

        Molecular Weight: 1068.1

        Purity: >90% (HPLC)

      • Storage & Shipping

        Shipping requirement: Ambient

        Storage conditions: -20°C

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